The liver is one of the essential organs of our body, it means that without that we can’t be alive. It does fundamental functions such as removing toxic ingredients and bacteria, preventing infections, processing nutrients, drugs, and hormones, fixing immune reactions and many other functions. There are several reasons for the failure of the liver; when a liver suffers from acute liver failure (Fulminant hepatic failure) it causes signs and symptoms and leads to hospitalization. Liver failure can be because of long term health problems or in consequence of using drugs, another thing can cause liver failure is infection or cirrhosis of the liver. When one of our organs don't function properly, signs of the disorder appear and other organs try to increase their activity to compensate for deficiencies. But sometimes one organ completely and irreversibly fails. In this situation, we should bring out the failure organ and replace it with someone else’s organ or an artificial one. Today many patients who suffer from liver failure disease are survived by liver transplantation. Liver transplantation is a treatment option for a person who has vital function problems as a result of chronic diseases. In this surgery, the failing liver is extracting from the body and replace with whole or part of a healthy liver from a brain-dead or living donor. Unfortunately, the number of people who need a liver to transplant is far more than donors. Patients who decide to do this surgery should consider some points in choosing their transplant center, for example, statistics of the patients reveal information about the percentage of the successful surgeries or survival rates, costs are important too, this varies from costs before surgery to doctor visit charge after transplantation. Finally, the devices which are used in that center are really effective in your surgery. According to international databases, more than 25000 successful liver transplantation yearly is done all over the world, and it is increasing each year. 79 percent are brain-dead donors and 21 percent are living donors. There are nine liver transplantation centers in Iran. Shiraz is the first center with more than twenty years experience and about 5000 transplantation, the second one is Imam Khomeini hospital’s center with about 1000 transplantation. Between these centers only in Shiraz center patients can receive a liver from a living donor. The survival rate years after surgery are comparable to (Europe and America)’s surgeries. For example survival rate after five years in Iran is 77% in adults in 2018, while according to “MedicalNewsToday. Com” this rate in 2018 was 72 percent in other countries. During the period of 20 years, 77.4 percent of patients in Iran are alive after the surgery which is unbeatable record for this kind of operation. In the case of financial issues, there is a considerable difference between the cost of this surgery in Iran and other countries. You can benefit from the same quality at a lower cost in Iran. Like every surgical operation, Complications are Inevitable, and there are some complications because of Hospitalization which is possible for every patient. Some of them which occur as a result of LT are non-functioning or low-function of the new liver. If the new liver’s function doesn’t become better sufficiently and with an acceptable rate, the patient needs to emergency second transplant to survive. Finally, rejection is a threat for receivers. It causes disorders in liver and rejection is because of immune reaction and immune cells hurt the new organ.